糖尿病・内分泌グループ

糖尿病・内分泌グループ

「膵β細胞研究グループ」・「内分泌研究グループ」の2つの研究テーマで、臨床応用を意識した基礎研究を精力的に行っております。また、糖尿病・内分泌疾患に関する多数の自主臨床研究を積極的に行い、当グループが糖尿病内分泌疾患の独自の情報発信源となれるよう努力しています。

基礎研究

臨床研究

 当グループは糖尿病・内分泌疾患に関する多数の自主臨床研究を積極的に行っており、日常診療の中での治療薬や治療法、特殊検査についての観察研究や介入研究のほか、北海道内の関連施設の多数の先生方のご協力のもと、多施設共同研究の形で標準的糖尿病薬物治療の確立に向けた研究を行っています。また、持続血糖モニターを用いて解析した血糖変動と膵β細胞機能との関連などといった2型糖尿病の病態に迫る研究もすすめています。
 臨床研究の基盤にあるものとして、個々の症例を深く掘り下げ検討し、新たな知見や臨床研究のアイデアを得ることが重要です。当科では経過や診断、治療において世界的に共有すべき症例について、積極的に学会発表や英文での症例報告を行っています。

＜主な症例報告の発表論文＞

1)Manda S, Miya A, Nakamura A, Kameda H, Atsumi T. A pitfall in diagnosing type B insulin resistance syndrome: suspected antibody interference in a patient with insulin allergy. J Diabetes Investig. 2026;17: 546-548
2)Handa T, Kameda H, Oe Y, Sakai K, Nakamura A, Atsumi T. A Novel ARMC5 Germline Variant in Siblings with Primary Bilateral Macronodular Adrenal Hyperplasia and Colonic Adenomas. JCEM Case Rep. 2025;3: luaf197
3)Onodera S, Miyamae M, Higuchi I, Nashimoto S, Nakamura A, Sugawara M, Takekuma Y. The Effect of Sacubitril/Valsartan on Urinary C-Peptide Excretion and Endogenous Insulin Secretory Capacity in a Patient with Type 2 Diabetes: A Case Report. J Pharm Health Care Sci. 2025;11: 75
4)Iesaka H, Kameda H, Miya A, Nomoto H, Cho KY, Nakamura A, Abe T, Shinohara N, Atsumi T. Fulminant ACTH decrease following diabetic ketoacidosis induced by immune checkpoint inhibitor combination therapy with nivolumab and ipilimumab: A case report. Medicine (Baltimore). 2023;102: e36664
5) Iesaka H, Nomoto H, Atsumi T. Alcoholic ketoacidosis presenting with hypoglycemia exacerbated by an SGLT2 inhibitor in a nondiabetic patient. Mayo Clin Proc., 2023, in press
6) Ofuji Y, Nomoto H, Miya A, et al. Urethral injury related to peri-urethral abscess as a complication of self-catheterization in an older patient with type 2 diabetes. Geriatr Gerontol Int. 2022;22(10):894-895.
7) Takahashi Y, Kameda H, Miya A, et al. Lymphocytic panhypophysitis and anti-rabphilin-3A antibody with pulmonary sarcoidosis. Pituitary. 2022;25(2):321-327.
8) Yokozeki K, Nomoto H, Atsumi T. Diabetic Chorea. J Gen Intern Med. 2022;37(10):2573-2574.
9) Oe Y, Kameda H, Nomoto H, et al. Favorable effects of burosumab on tumor-induced osteomalacia caused by an undetectable tumor: A case report. Medicine (Baltimore). 2021;100(46):e27895.
10) Chiba K, Kameda H, Miya A, et al. Letter to the Editor: False Hypercortisolemia Due to Abnormal Albumin-Cortisol Binding in a Patient with Familial Dysalbuminemic Hyperthyroxinemia. Thyroid. 2022;32(2):219-220.
11) Oba-Yamamoto C, Kameda H, Miyoshi H, et al. Acromegaly Cases Exhibiting Increased Growth Hormone Levels during Oral Glucose Loading with Preadministration of Dipeptidyl Peptidase-4 Inhibitor. Intern Med. 2021;60(15):2375-2383.
12) Yamauchi Y, Kameda H, Omori K, et al. Severe infection including disseminated herpes zoster triggered by subclinical Cushing’s disease: a case report. BMC Endocr Disord. 2021;21(1):84. Published 2021 Apr 27.
13) Yuno A, Kenmotsu Y, Takahashi Y, et al. Successful management of a patient with active Cushing’s disease complicated with coronavirus disease 2019 (COVID-19) pneumonia. Endocr J. 2021;68(4):477-484.
14) Miya A, Nakamura A, Kameda H, et al. Gitelman’s syndrome with hyperphosphatemia, effectively responding to single oral magnesium oxide administration: A case report. Medicine (Baltimore). 2019;98(28):e16408.
15) Sekizaki T, Kameda H, Oba C, et al. Nivolumab-induced hypophysitis causing secondary adrenal insufficiency after transient ACTH elevation. Endocr J. 2019;66(10):937-941.
16) Nomoto H, Kameda H, Nakamura A, et al. Breakdown of Autonomously Functioning Thyroid Nodule Accompanied by Acromegaly After Octreotide Treatment. Front Endocrinol (Lausanne). 2019;10:131.
17) Shibayama Y, Kameda H, Ota S, et al. Case of fulminant type 1 diabetes induced by the anti-programmed death-ligand 1 antibody, avelumab. J Diabetes Investig. 2019;10(5):1385-1387.
18) Yanagiya S, Cho KY, Nakamura A, et al. The effect of everolimus on refractory hypoglycemia in a patient with inoperable metastatic insulinoma evaluated by continuous glucose monitoring. Intern Med. 2018;57(17):2527-2531.
19) Nomoto H, Miyoshi H, Nakamura A, et al. Potential importance of histopathological analysis in thyroidal diseases with high serum IgG4 levels. Intern Med. 2018;57(3):453.
20) Nomoto H, Miyoshi H, Nakamura A, et al. A case of osteomalacia due to deranged mineral balance caused by saccharated ferric oxide and short-bowel syndrome: A case report. Medicine (Baltimore). 2017;96(39):e8147.
21) Kondo A, Nakamura A, Takeuchi J, et al. Insulin-Induced Distant Site Lipoatrophy. Diabetes Care. 2017;40(6):e67-e68.

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